Should a healthy adult take an NAD booster (NMN or NR) to slow aging?

Peter AttiaMD · longevity physician, founder of Early Medical

No. The case is still theoretical, and the human results claiming benefit do not hold up.

What it rests onConcedes NAD declines with age and that NMN raises circulating NAD, but argues intracellular NAD is the variable that matters, that human studies conflict, and that the trial showing benefits used an unvalidated biological-age calculator and a six-minute walk test that cannot detect fitness differences in healthy adults.

David A. SinclairPhD · Professor of Genetics, Harvard Medical School

NAD precursors are a central part of his longevity protocol and he reviews them as promising.

What it rests onDedicates a full Lifespan episode to NAD boosters (NR, NMN, IV drips), with a section on his own protocol for longevity molecules. The same show notes carry a published dosage correction, which is a signal about the channel rather than about the compound.