Shanna H. SwanPhD · environmental and reproductive epidemiologist, Icahn School of Medicine at Mount Sinai
Yes, and the evidence is in people, not just in products.
What it rests onA human cohort measuring exposure biomarkers in mothers and a developmental outcome in their sons, designed around a reproducible rodent finding, and extended since by 22 further papers including the TIDES multicentre cohort.
Source: pubmed.ncbi.nlm.nih.gov ↗
Joe SchwarczPhD · chemist, director of the McGill Office for Science and Society
The doses are minute and there is no outcome data in people.
What it rests onDose arithmetic and the absence of human outcome data. On accumulation he says: We have no data on which to build a theory.
Source: mcgill.ca ↗
Swan's measured outcome is in male infants exposed in the womb. Schwarcz is answering for a general adult drinking bottled water. They are not describing the same person, and a general adult user is closer to Schwarcz's population than to Swan's. Note also that they are not describing the same exposure: Swan is measuring phthalate and bisphenol chemistry, Schwarcz is arithmetic on nanoplastic particle mass.
Both accept that phthalates and bisphenol A interfere with hormone signalling at low concentrations, both accept that human outcome evidence is thinner than laboratory and animal evidence, and both recommend a strikingly similar set of kitchen swaps. Schwarcz also keeps endocrine disruptors during pregnancy and early childhood on his own worry list, which is precisely Swan's population.
For Schwarcz, human outcome data at real-world doses, which the AGD line of work is the closest thing to; he would want it in adults with hard endpoints. For Swan, failure of the AGD associations to replicate in the larger cohorts, or a demonstration that the anogenital index is measuring body proportion rather than androgen exposure, which is the objection the cosmetics industry raised in 2006 and which was never conceded.
You do, and your call is dated, kept, and yours to change. Follow the people you already trust and what they publish turns into a short daily practice.
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